It's one of the thing that's made the most difference in my symptoms...
A New Approach to ME/CFS Fatigue
Is ME/CFS or Long COVID keeping you from the life you want to live?
Oxaloacetate CFS 500 mg is a medical food developed for dietary management of fatigue associated with ME/CFS. More energy for the life you miss. Clinically studied in people with ME/CFS and supported by four peer-reviewed publications.
4
Peer Reviewed Publications
270+
Participants
63%
Top Fatigue Reduction
Based on the results of peer-reviewed clinical trials, doctor and patient reports and the existing body of research investigating Oxaloacetate, the U.S. Food and Drug Administration has allowed the following structure/function claim for Oxaloacetate CFS™:
“Oxaloacetate may help alleviate the physical and mental fatigue associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).”
CUSTOMER TESTIMONIALS
Real People. Real Experiences.
After more than a decade of suffering with ME/CFS, Nate found Oxaloacetate CFS to be life-changing.
Approved by Doctors & Health Professionals
Patented Biotechnology Manufactured in the
USA with Domestic and Global Ingredients
Tested in Peer-Reviewed Clinical Trials
CLINICAL EVIDENCE DATA
Four Peer-Reviewed Clinical Study Publications
Research published in the Journal of Translational Medicine, Frontiers in Neurology and Frontiers in Neuroscience journals finds oxaloacetate improves ME/CFS and Long COVID symptoms including:
- Physical fatigue
- Mental fatigue
- Cognition
- Symptom burden
- Upright activity
The publications draw on clinical trials enrolling approximately 270 participants: a controlled dose-ranging study, two randomized double-blind controlled trials, and an additional analysis examining the relationships among fatigue, cognition and physical function.
Buy NowME/CFS patients showed an improvement in mental and physical fatigue by 25% - 35%.
FRONTIERS IN NEUROLOGY
25% to 35%
40.5% of ME/CFS patients are enhanced responders, with an average fatigue reduction of 63%.
BATEMAN HORNE CENTER RANDOMIZED
63%
Long COVID patients showed a reduction in fatigue by up to 46.8%.
SPRINGER NATURE
46.8%
WHY OXALOACETATE: THE SCIENCE
CFS Patients Have Low Oxaloacetate Levels
Metabolomic studies in ME/CFS patients vs. normal controls indicate that oxaloacetate levels are significantly reduced in the plasma of ME/CFS patients.
The Journal of Molecular Biosystems published a 2017 clinical trial showing a statistically significant shortage of oxaloacetate in ME/CFS patients compared to a normal control group.
Ordinary foodstuffs do not contain enough oxaloacetate to overcome this shortage, so the dietary management of ME/CFS patients cannot be achieved by the modification of the normal diet alone.
SHOP
Oxaloacetate CFS – 500mg.
A Medical Food For Chronic Fatigue Syndrome.
Oxaloacetate may help alleviate physical and mental fatigue symptoms associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).*
What is A Medical Food?
Medical Foods
Are always to be used only under the supervision of a licensed healthcare provider. Provide support for the nutritional management of a specific disease or condition that has distinct and established nutritional requirements. Support those who have trouble digesting and absorbing food and certain nutrients and cannot nutritionally manage their condition through diet modification alone.
Dietary Supplements
Provide supplementary nutritional support for healthy people. Are intended to affect the normal structure or function of the human body. While benaGene is a dietary supplement, Oxaloacetate CFS is not.
Oxaloacetate CFS is a medical food, a classification distinct from dietary supplements.
Expert Insights & Clinical Perspectives
Dr. Vernon: New Clinical Data on Oxaloacetate As A Breakthrough Treatment for ME/CFS and Long COVID
Based on the results of peer-reviewed clinical trials, doctor and patient reports and the existing body of research investigating Oxaloacetate, the U.S. Food and Drug Administration has allowed the following structure/function claim for Oxaloacetate CFS: “Oxaloacetate may help alleviate the physical and mental fatigue associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).”
Oxaloacetate CFS Data Presented at The 2025 International ME/CFS Conference
Watch the ME/CFS Research Foundation's featured lecture on Oxaloacetate treatment for ME/CFS and Long COVID by Terra Biological Chief Science Officer Alan Cash.
To explore more presentations from the 2025 International ME/CFS Conference, visit the full YouTube conference playlist.
For more information on ME/CFS Research Foundation, visit the ME/CFS Research Foundation website.
International Association for Chronic Fatigue Syndrome Presents
The Groundbreaking Research on Oxaloacetate for ME/CFS and Long COVID
David Lyons Kaufman, MD is a world-renowned expert in ME/CFS and fierce patient advocate. He is the founder of the Center for Complex Diseases and a member of Stanford University’s ME/CFS Research Center.
Free Patient Support Resources
Oxaloacetate CFS includes patient support materials such as guided meditations, a wellness journal, and educational blogs to support your patient’s healing journey. These resources are designed to provide ongoing guidance and support clinical care.
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Wellness journal
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Guided meditations
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HSA/FSA Approved
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Wellness journal prompts
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Monthly Wellness Blogs
If you would like to receive these journals at your clinic, please email us at info@oxaloacetatecfs.com with your shipping information and how many journals you would like.
Request Journals For Your Clinic
