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It’s Time To Start Living Again

Is ME/CFS or Long COVID keeping you from the life you want to live?

You deserve answers backed by science and a treatment approach grounded in clinical research. Our goal is to help you reclaim your energy, improve your quality of life, and get back to the moments that matter most.

Oxaloacetate CFS 500 mg is a medical food that has been clinically studied in people with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Clinical studies have shown significant reductions in fatigue, helping many patients take meaningful steps toward living life more fully.

After more than a decade of suffering with ME/CFS, Nate found Oxaloacetate CFS™ to be life-changing. 

Dr. Vernon: New Clinical Data on Oxaloacetate As A Breakthrough Treatment for ME/CFS and Long COVID

Dr. Vernon: New Clinical Data on Oxaloacetate As A Breakthrough Treatment for ME/CFS and Long COVID

Based on the results of peer-reviewed clinical trials, doctor and patient reports and the existing body of research investigating Oxaloacetate, the U.S. Food and Drug Administration has allowed the following structure/function claim for Oxaloacetate CFS:

Oxaloacetate may help alleviate the physical and mental fatigue associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Groundbreaking Clinical Trial Data

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with ME/CFS

In Bateman Horne Center’s 2024 randomized, controlled clinical trial published by Frontiers in Neurology, 3 months of daily Oxaloacetate CFS yielded:

  • A significant reduction of fatigue by an average of 25 to 35%
  • Improvements in both mental and physical fatigue
  • 40.5% of the oxaloacetate group were classified as "enhanced responders," with an average fatigue reduction of 63%

Oxaloacetate CFS Data Presented at The 2025 International ME/CFS Conference

Watch the ME/CFS Research Foundation's featured lecture on Oxaloacetate treatment for ME/CFS and Long COVID by Terra Biological Chief Science Officer Alan Cash.

To explore more presentations from the 2025 International ME/CFS Conference, visit the full YouTube conference playlist.

For more information on ME/CFS Research Foundation, visit the ME/CFS Research Foundation website.

Clinically Proven To Lower Fatigue

Oxaloacetate CFS is clinically proven to lower fatigue in the latest study peer reviewed and published by Springer Nature’s Journal of Translational Medicine.

In the first 6 weeks of daily Oxaloacetate CFS…

  • Chronic Fatigue Syndrome patients showed a reduction in fatigue by up to 33.3%
  • Long COVID patients showed a reduction in fatigue by up to 46.8%

CFS Patients Have Low Oxaloacetate Levels

Metabolomic studies in ME/CFS patients vs. normal controls indicate that oxaloacetate levels are significantly reduced in the plasma of ME/CFS patients.

The Journal of Molecular Biosystems published a 2017 clinical trial showing a statistically significant shortage of oxaloacetate in ME/CFS patients compared to a normal control group

Ordinary foodstuffs do not contain enough oxaloacetate to overcome this shortage, so the dietary management of ME/CFS patients cannot be achieved by the modification of the normal diet alone.

Study Reference:
Germain A, Glass KA, Eckert MA, Giloteaux L, Hanson MR. Temporal Dynamics of the Plasma Proteomic Landscape Reveals Maladaptation in ME/CFS Following Exertion.Molecular & Cellular Proteomics. 2025;24(12):101467. doi:10.1016/j.mcpro.2025.101467

Oxaloacetate CFS Reviews

  • Medical Foods

    Are always to be used only under the supervision of a licensed healthcare provider. Provide support for the nutritional management of a specific disease or condition that has distinct and established nutritional requirements. Support those who have trouble digesting and absorbing food and certain nutrients and cannot nutritionally manage their condition through diet modification alone.

  • Dietary Supplements

    Provide supplementary nutritional support for healthy people. Are intended to affect the normal structure or function of the human body. While benaGene is a dietary supplement, Oxaloacetate CFS is not.

    Oxaloacetate CFS is a medical food, a classification distinct from dietary supplements.

  • Patented Biotechnology Manufactured in the USA with Domestic and Global Ingredients

  • Tested in Peer-Reviewed Clinical Trials

  • Approved by Doctors & Health Professionals

International Association for Chronic Fatigue Syndrome Presents

The Groundbreaking Research on Oxaloacetate for ME/CFS and Long COVID

David Lyons Kaufman, MD is a world-renowned expert in ME/CFS and fierce patient advocate. He is the founder of the Center for Complex Diseases and a member of Stanford University’s ME/CFS Research Center.